Cyclooxygenase-2 and Colorectal Cancer Chemoprevention: The β-Catenin Connection: Figure 1.
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چکیده
منابع مشابه
Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection.
Colorectal cancer poses a major clinical challenge in the developed world where this disease is common. Recent findings suggest that the prostaglandin E(2), the proinflammatory product of elevated cyclooxygenase-2 activity in colon cancer, stimulates cancer cell growth through a G protein-dependent signaling pathway coupling the prostaglandin EP2 receptor to beta-catenin control. These findings...
متن کاملCyclooxygenase-2 and Colorectal Cancer Chemoprevention: The B-Catenin Connection
Colorectal cancer poses a major clinical challenge in the developed world where this disease is common. Recent findings suggest that the prostaglandin E2, the proinflammatory product of elevated cyclooxygenase-2 activity in colon cancer, stimulates cancer cell growth through a G protein– dependent signaling pathway coupling the prostaglandin EP2 receptor to B-catenin control. These findings pro...
متن کاملSerpinB3 upregulates the Cyclooxygenase-2 / β-Catenin positive loop in colorectal cancer
Colorectal cancer is characterized by aberrant Cyclooxigenase-2 (COX-2) and β-Catenin pathways. Recently, the protease inhibitor SerpinB3 has been described overexpressed in more advanced stages of this tumor. Aim of the study was to explore the possible relationship between these molecules in this setting. We evaluated colorectal cancer specimens from 105 patients and a positive correlation be...
متن کاملExpression of β-Catenin and Cyclooxygenase 2 in Colorectal Carcinoma: An Immunohistochemical Study
The Wnt/β-catenin pathway plays an important role in the genesis of familial adenomatous polyposis, the most common form of inherited colorectal carcinoma (CRC). Also, the inflammatory bowel diseases (IBDs) predispose to cancer development; and cyclooxygenase 2 (COX-2) seems to be pivotal in their pathogenesis. This study aimed to investigate the relationship between the expression of COX-2 pro...
متن کاملThe Role of Cyclooxygenase-2 in Signaling Pathways Promoting Colorectal Cancer
Colorectal cancer is one of the most common cancers in the world. Various factors are involved in the development and progression of this disease. One of these agents is cyclooxygenase-2 (COX-2). COX-2 is a product of the PTGS2 gene and converts free arachidonic acid to prostaglandins. COX-2 is not naturally expressed in most normal cells. Noticeably, the increased expression of COX-2 has been ...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2006
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-06-2233